Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.
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چکیده
منابع مشابه
Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.
The unique role of antigen presentation by major histocompatibility complex (MHC) class I molecules is to enable the immune system to monitor the internal contents of intact cells. Cytotoxic T cells (CTLs) recognize peptide bound to class I molecules on the cell surface, detect virus infection or malignant transformation, and destroy the diseased cell (1). A key piece of information in the unde...
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The transporter associated with antigen processing (TAP) plays a key role in adaptive immunity by translocating proteasomal degradation products from the cytosol into the endoplasmic reticulum lumen for subsequent loading onto major histocompatibility (MHC) class I molecules. For functional and structural analysis of this ATP-binding cassette complex, we established the overexpression of TAP in...
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The ATP-binding cassette (ABC) transporter TAP translocates peptides from the cytosol to awaiting MHC class I molecules in the endoplasmic reticulum. TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleotide binding domain (NBD). However, the role of ATP in peptide binding and translocation is poorly understood. We present biochemical and functional evidence that the NBD...
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15 صفحه اولVaricellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (TAP) plays an essential role in MHC class I-restricted antigen presentation, as TAP imports peptid...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.2.341